- iCNS Strategic Board

The iCNS newsletter - September 2025
by iCNS 17 Sep '25

17 Sep '25

View this email in your browser (https://mailchi.mp/3c362b790240/icns-newsletter-10982692?e=0b1f2e02c1) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… September 2025 Dear iCNS participants, Welcome back! We hope you’ve all had a relaxing summer and started the new academic year with renewed energy and inspiration. This autumn promises to be another exciting phase for iCNS. We’re pleased to see more researchers have joined the program. Several PhD candidates and postdocs have made their start as you might have seen on LinkedIn, and more vacancies will be filled in the coming period. It’s great to witness our community steadily growing and new collaborations taking shape within and between the work packages. We’re also looking forward to the upcoming meeting with our International Advisory Board mid-November. It will be an important moment to reflect on our plans and progress, receive strategic feedback, and further strengthen the scientific direction of iCNS. Since July, Sabina van der Zanden has taken up the role of iCNS Project Manager. Her experience and dedication have already made a great difference, and we’ve very much enjoyed working with her. Later this month, Sabina will go on maternity leave, and we wish her all the best during this special time! Of course, interim support will be available during her absence. Finally, a special moment for the Dutch neuroscience community: Koningin Máxima will soon attend the 40-year anniversary celebration of the Netherlands Brain Bank. It’s wonderful to see such visible interest in scientific research using human brain tissue, and it underscores the importance of the work we are working on. We wish you a smooth and inspiring start to the new season — and we look forward to what’s ahead! Best regards, Inge Huitinga, Paul Lucassen & Mario van der Stelt Read more on the 40-year anniversary of the Netherlands Brain Bank Article by the Netherlands Brain Bank (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) (Dutch) Article by NRC (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) (Dutch) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… Kind Reminder to Register Consortium Meeting - December 16th, Kasteel Oud Poelgeest, Oegstgeest Young Researchers Meeting - December 11th, Science Park, Amsterdam New Additions to the iCNS Team! From left to right: Daan van der Vliet - Postdoc with Femke de Vrij (EMC) Daniël Huitema - PhD with Marc Baggelaar (UU) Tina Zajec Hudnik - PhD with Bert Janssen (UU) Learn more about our new colleagues, join the conversation and stay connected with our growing iCNS community via LinkedIn (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) ** A word from the NBB Tissue Dissemination Officer ------------------------------------------------------------ Hi everyone! Since June 15th I’ve been working at the Netherlands Brain Bank as Tissue Dissemination Officer, with part of my position dedicated to iCNS. I obtained my Master’s in Neuroscience at Radboud University and currently, I am in the finalizing stage of my PhD at Vrije Universiteit Amsterdam under the supervision of Prof. Sabine Spijker. My PhD research focused on how social stress affects memory in mice, especially through changes in perineuronal nets in the hippocampus. Along the way I worked with behavioral assays, stereotactic surgery, chemogenetics, electrophysiology, and single-cell proteomics using LCM and mass spectrometry. https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… Within iCNS my role is to make sure that tissue dissemination supports the projects of our consortium members. I advise researchers and students on suitable material, coordinate and oversee sample preparation, and train students in handling and processing tissue. I really enjoy these interactions because they connect my scientific background with the collaborative spirit of iCNS. It’s rewarding to help colleagues match the right tissue to their questions and to see how this becomes the starting point for exciting experiments. Tissue dissemination is at the foundation of iCNS. By ensuring quality and sharing knowledge, I hope to contribute to smoother workflows and stronger results across the consortium. I’m looking forward to meeting more of you, hearing about your projects, and supporting your research in any way I can. Best regards, Payam Safavi Meet our International Advisory Board The IAB brings together leading scientists and key stakeholders to provide external strategic advice to iCNS. It supports maximizing impact, aligning with global initiatives, and guiding talent selection. Its five chambers represent the scientific community (S), patients (P), clinicians (C), industry (I), and ethics (E). Learn more about our esteemed IAB members by clicking on their pictures. https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… From left to right, top to bottom: IAB-S: Guus Smit - Vrije Universiteit Amsterdam (NL) IAB-S: Elly Hol - Universiteit Utrecht (NL) IAB-S: Schahram Akbarian - Mount Sinai School of Medicine (USA) IAB-S: Staci Bilbao - Duke University (USA) IAB-S: Elisabeth Binder - Max-Planck Institute of Psychiatry (DE) IAB-S: Benjamin Cravatt - Scripps Research (USA) IAB-S: Boudewijn Lelieveldt - Leiden Universitair Medisch Centrum (NL) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… From left to right, top to bottom: IAB-P: Marieke van Eijkelen - Plusminus (NL) IAB-P: Dirk-Jan Saaltink - Dutch Brain Foundation (NL) IAB-C: Sachin Patel - Feinberg School of Medicine at Northwestern University (USA) IAB-C: Brenda Penninx - Amsterdam Universitair Medisch Centrum (NL) IAB-C: Josef Priller - University of Edinburgh & Charite University Berlin (UK/DE) IAB-I: Casper Hoogenraad - Genentech Research & Universiteit Utrecht (NL) IAB-I: Uwe Grether - Roche (CH) IAB-E: Gerben Meynen - Vrije Universiteit Amsterdam (NL) ** Meet our iCNS Data Manager: Eric Hoekstra ------------------------------------------------------------ Neuroscience first caught my attention during my bioinformatics bachelor's degree, and joining the Holtman lab in 2021 gave me the chance to explore it. That’s also when I became involved with the Netherlands Neurogenomics Database (NND), where we aim to clean and standardize the rich clinical and neuropathological data collected by the Netherlands Brain Bank (NBB). My first project focused on developing machine learning models to extract symptoms from textual NBB data, and I continued this work during my graduation internship by building models that predict donors’ main diagnoses based on their symptoms. https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… After these experiences, I was excited to officially join the Holtman lab as a technician to help further develop the NND. Within this project, my main responsibilities include building the data infrastructure for the NND and our research group, developing the publicly accessible NND website, and supporting colleagues wherever data-expertise is needed. The NND will become a valuable resource for the iCNS consortium. By bringing together the standardized clinical, neuropathological and genetic data, we all can gain a deeper understanding of the NBB donors’ their backgrounds, supporting more informed research within the consortium. Within the iCNS consortium, my role is to develop a data-sharing infrastructure where we can securely store and share our research data and complement this with the rich donor information available in the NND. For me, the most rewarding part of this work is seeing how well-organized data enables researchers to study psychiatric and neurological disorders more effectively. Knowing that the information I help structure can lead to new insights makes the role meaningful. I look forward to seeing all of you in December at the consortium meeting! Publications (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) A Novel Cyclopropenyl Fatty Acid Library Reveals Tissue-Specific Preferences for Regulatory T Cell Uptake Through Click-Chemistry. Heieis, G., Reinalda, L., Bogue, L. I., Steuten, K., Corrigan, C., Wang, X., Bertheussen, K., El Boujadayni, M., Sinclair, L. V., Van der Stelt, M., Everts, B., Finlay, D. K., & Van Kasteren, S. I. The iCNS-affiliated groups of Van Kasteren and Van Der Stelt with collaborators from the immunology field have developed a new method in which they can measure uptake of different fatty acids by immune cells. The major breakthrough is the ability to quantify the uptake of different fatty acids of single cells, and for the first time, whilst keeping the cells alive. This method enables researchers to explore how the availability of specific nutrients influences cellular growth, differentiation, and responses in disease. This technology will feature heavily in multiple iCNS projects, so stay tuned! Read the full article (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) Gi Signaling Controls Microglial Surveillance and Neuronal Synchronization. Van den Bosch, A. M., & Hamann, J. Read the full article (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) Cross-Analysis of Single-Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging Polzer, O., Kinloch, E., Lucassen, P. J., Salta, E., & Fitzsimons, C. P. Read the full article (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) Missed The Last iCNS Newsletter? If our last newsletter got lost in your summer inbox, or you would simply like to revisit the July edition - you can find it here (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) . https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… mailto:contact@i-cns.nl https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… Want to change how you receive these emails? You can update your preferences (https://i-cns.us1.list-manage.com/profile?u=9153e18ffe39dd83583a27335&id=10…) or unsubscribe (https://i-cns.us1.list-manage.com/unsubscribe?u=9153e18ffe39dd83583a27335&i…) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…

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Invitation to attend the iCNS Consortium Meeting – December 16, 2025
by Sabina van der Zanden 17 Sep '25

17 Sep '25

Dear Members of the iCNS Strategic Board, I am pleased to inform you that this year’s iCNS Consortium Meeting will take place on Tuesday, December 16, 2025, from approximately 09:00 to 17:00 (Amsterdam time). As a valued member of our Strategic Board, we would like to warmly invite you to join the meeting online. During the meeting, several scientists, PhD candidates, and postdoctoral researchers will present their project plans and provide updates on the progress of their ongoing work. These presentations are intended to keep all members of the consortium informed and to encourage constructive discussion and feedback. If you are interested in attending the meeting online, we kindly ask you to complete the following form (you can also indicate that you are unable to attend): https://forms.gle/AtHp6nzNwMwiGFLD8 At a later stage, you will then receive the connection details to join the meeting. We hope you will be able to participate and contribute with your insights to the discussions. With kind regards, Sabina Y. van der Zanden, PhD (she/her) Project Manager - Institute for Chemical Neuroscience (iCNS) University of Amsterdam [cid:image001.png@01DC27BE.B80950C0] Available on Mon | Wed | Thu | Fri +31651327222 PO Box 94216 | 1090 GE Amsterdam | Room C2.122a Sciencepark 904 | 1098 XH Amsterdam | The Netherlands www.uva.nl<http://www.uva.nl/> / www.i-cns.nl<http://www.i-cns.nl/> I choose to work flexibly and may send emails outside normal office hours. No need to respond to my emails outside yours.

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Minutes iCNS Strategic Board meeting June 18th 2025.
by Sabina van der Zanden 12 Sep '25

12 Sep '25

Dear iCNS Strategic Board members, dear EB, I would like to take this opportunity to share the minutes of the SB meeting held on June 18, 2025, which you will find attached or via the following link: [?docx icon] 20250618-Minutes-SB-Meeting.docx<https://amsuni.sharepoint.com/:w:/r/sites/FNWI_ORG_SILS_iCNS-ProjectManagem…> My name is Sabina van der Zanden, and since July 1st I have joined iCNS to support our multidisciplinary research efforts at the interface of chemistry and neuroscience. I hold a PhD in biomedical research, gained experience in cancer drug development as a senior scientist at Leiden University Medical Center, and more recently worked as a project manager at the Institute for Chemical Immunology (ICI). At the end of this month, I will be going on maternity leave, and I will return mid-January. In the meantime, you can always reach out to my colleague Ineke Brouwer (i.brouwer(a)uva.nl), who will be my replacement during this period. I look forward to working with you and contributing to the success of iCNS. Best regards, Sabina Y. van der Zanden, PhD (she/her) Project Manager - Institute for Chemical Neuroscience (iCNS) University of Amsterdam [cid:image001.png@01DC104F.88F4D600] Available on Mon | Wed | Thu | Fri +31651327222 PO Box 94216 | 1090 GE Amsterdam | Room C2.122a Sciencepark 904 | 1098 XH Amsterdam | The Netherlands www.uva.nl<http://www.uva.nl/> / www.i-cns.nl<http://www.i-cns.nl/> I choose to work flexibly and may send emails outside normal office hours. No need to respond to my emails outside yours.

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The iCNS newsletter - July 2025
by iCNS 18 Jul '25

18 Jul '25

View this email in your browser (https://mailchi.mp/839a891b06f3/icns-newsletter-10980679?e=0b1f2e02c1) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… July 2025 Dear iCNS participants, Welcome to our second newsletter, highlighting some recent iCNS-related developments and celebrating the progress of our project. First off, we are excited to welcome Sabina van der Zanden as our new iCNS project coordinator and the new head of iCNS Project Management. She will be your main contact person from now on, and her earlier experience with the ICI gravitation program in Leiden is already proving to be invaluable. We are furthermore very pleased to welcome several new hires that started recently. It is great to see some collaborations starting to take shape across work packages, and, with more hires on the way, it is an inspiring start of the program. Also, we recently had our first meeting with the iCNS Strategic Board, where the Executive Board gathered with senior representatives, i.e. the deans or research directors, from each host institute/faculty of the consortium, who serve as ‘critical friends’ of iCNS and can help provide strategic advice. Following an introductory round and a short presentation by Paul and Inge on the main framework and ambitions of iCNS, we had a lively and constructive discussion with them on our aims, strategy, on how to further connect, promote more collaboration and ultimately embed iCNS for the future. We are furthermore preparing for our yearly iCNS consortium meeting on December 16th in Oegstgeest, and for the young researchers meeting in Amsterdam on October 24th. As we continue on this journey together, we wish you all a lovely and relaxing break for now, and we look forward to the exciting developments ahead. Have a great summer! Best regards, Inge Huitinga, Paul Lucassen & Mario van der Stelt https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… Mark Your Calendars iCNS Consortium Meeting - December 16th, Oegstgeest Young Researchers Meeting - October 24th, Amsterdam (PhD’s and Postdocs only) New Additions to Our Team! From left to right, top to bottom: Tijn Vleeshouwer - PhD (UL) Jessica Hoang - PhD (UL) Eric Hoekstra - Data Manager (UMCG) Maxime Boven - Project en Communicatiemedewerker (NIN) Payam Safavi - Tissue Dissemination Officer & Research technician (NIN) Sabina van der Zanden - Senior Project Manager (UvA) ** Sabina van der Zanden: Reflections on Her First Days ------------------------------------------------------------ As of July 1st, 2025, I’ve joined iCNS as the new Senior Project Manager, and I’m very excited to introduce myself to all of you! I have a background in molecular cell biology and completed my PhD in the group of Jacques Neefjes in 2021. Since then, I worked as a postdoc and later as a senior scientist at LUMC, focusing on the development of anti-cancer drugs, particularly anthracyclines. Over the years, I’ve had the opportunity to contribute to both fundamental and clinical research. During the past 2.5 years, I discovered a new passion—project management—while working for the NWO Gravitation program Institute for Chemical Immunology (ICI). I love working together with people from diverse backgrounds and creating structure in complex, multidisciplinary projects. At the same time, I appreciate being able to work independently and take ownership of the planning and organization. I also truly enjoy the interpersonal side—facilitating communication, supporting researchers, and helping everyone stay aligned. What makes project management within a scientific consortium especially rewarding for me is the chance to stay close to the science. With my academic background, I find the content genuinely interesting and feel motivated by the idea that my work contributes—indirectly but meaningfully—to advancing scientific knowledge and improving treatments for various diseases. At iCNS, I’ll be supporting our multidisciplinary research efforts at the exciting interface of chemistry and neuroscience. Over the past few weeks, I’ve received a very warm welcome from the UvA project management team and iCNS daily board. It’s been a great start, and I’m really looking forward to working with all of you to help achieve the goals of this inspiring consortium. One quick note: my fresh start at iCNS will be briefly paused, as I’ll be going on maternity leave at the end of September. During that time, Ineke Brouwer—who has already been serving as interim project manager—will take over. I look forward to returning in January 2026 and continuing our work together. Warm regards, Sabina van der Zanden Missed Our First Newsletter? Some of you may have missed our first newsletter. If you’d like to catch up or re-read, you can find it here (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) . ** Our Summer Greetings ------------------------------------------------------------ We wish you a wonderful summer and look forward to seeing you after the holidays! https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… mailto:contact@i-cns.nl https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… Want to change how you receive these emails? You can update your preferences (https://i-cns.us1.list-manage.com/profile?u=9153e18ffe39dd83583a27335&id=10…) or unsubscribe (https://i-cns.us1.list-manage.com/unsubscribe?u=9153e18ffe39dd83583a27335&i…) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…

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iCNS Consortium Meeting
by Ineke Brouwer 27 Jun '25

27 Jun '25

Dear members of the iCNS, With this email, I would like to inform you that the iCNS Consortium Meeting will take place on Tuesday December 16, 2025 in Kasteel Oud Poelgeest<https://www.kasteeloudpoelgeest.com/?gad_source=1&gad_campaignid=607631731&…> (in Oegstgeest, close to Leiden). It will be a full-day program. More details will follow, but, for now, please be sure to save the date! Kind regards, Ineke Brouwer, PhD (she/her) Project Manager University of Amsterdam Available on Mon | Tue | Thu | Fri +31614759507 PO Box 94216 | 1090 GE Amsterdam | Room C2.122a Sciencepark 904 | 1098 XH Amsterdam | The Netherlands www.uva.nl<http://www.uva.nl/> I choose to work flexibly and may send emails outside normal office hours. No need to respond to my emails outside yours.

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SAVE-THE-DATE: iCNS Consortium Meeting, 16-12-2025
by Ineke Brouwer 27 Jun '25

27 Jun '25

Dear members of the iCNS Strategic Board, With this email, I would like to inform you that the iCNS Consortium Meeting will take place on Tuesday December 16, 2025 in Kasteel Oud Poelgeest<https://www.kasteeloudpoelgeest.com/?gad_source=1&gad_campaignid=607631731&…> (in Oegstgeest, close to Leiden). As a member of the iCNS Strategic Board, you are most welcome to attend. If case travelling to Leiden is not feasible, we will offer the opportunity to participate online. It will be a full-day program. More details will follow, but, for now, please be sure to save the date! Kind regards, Ineke Brouwer, PhD (she/her) Project Manager University of Amsterdam Available on Mon | Tue | Thu | Fri +31614759507 PO Box 94216 | 1090 GE Amsterdam | Room C2.122a Sciencepark 904 | 1098 XH Amsterdam | The Netherlands www.uva.nl<http://www.uva.nl/> I choose to work flexibly and may send emails outside normal office hours. No need to respond to my emails outside yours.

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iCNS Strategic Board meeting - Agenda, EB Minutes Extract & Proposal Abstract (June 18)
by Naomi van der Most 16 Jun '25

16 Jun '25

Dear iCNS Strategic Board members and representatives, Ahead of our upcoming Strategic Board meeting on Wednesday, June 18th, from 17:00 to 18:00, please find attached the following documents for your preparation: * An extract of the Executive Board (EB) meeting minutes * The abstract of the iCNS proposal submitted to NWO The agenda for the meeting is outlined below: 17:00 – 17:20 | Introduction round 17:20 – 17:40 | Presentation of iCNS work plan 17:40 – 18:00 | Discussion Please use the Zoom link below to join the meeting: Join Zoom Meeting https://uva-live.zoom.us/j/88457135747 Meeting ID: 884 5713 5747 We look forward to meeting you soon and hearing your insights. If you have any questions in the meantime, please don’t hesitate to reach out. Best wishes, Naomi van der Most (Junior Project Manager, UvA), on behalf of; Inge Huitinga (UvA/NIN) Paul Lucassen (UvA) Mario van der Stelt (LU) Bart Eggen (UMCG) Lot de Witte (RUMC) Maarten Kole (NIN) Inge Holtman (UMCG) [cid:9da91aae-1e40-4e6f-b582-4d4070da0e91]

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iCNS Strategic Board Meeting
by Naomi van der Most 16 Jun '25

16 Jun '25

Naomi van der Most is inviting you to a scheduled Zoom meeting. Topic: iCNS Strategic Board Meeting Time: Jun 18, 2025 05:00 PM Amsterdam, Berlin, Rome, Stockholm, Vienna Join Zoom Meeting https://uva-live.zoom.us/j/88457135747 Meeting ID: 884 5713 5747 --- Join by SIP • 88457135747(a)zoomcrc.com --- Join by H.323 • 144.195.19.161 (US West) • 206.247.11.121 (US East) • 159.124.15.191 (Amsterdam Netherlands) • 159.124.47.249 (Germany) Meeting ID: 884 5713 5747

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iCNS Newsletter
by contact＠i-cns.nl 16 May '25

16 May '25

View this email in your browser (https://mailchi.mp/c73346859f5b/icns-newsletter?e=0b1f2e02c1) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… May 2025 Dear iCNS participants, A very warm welcome to all of you! We are very excited to bring you our very first newsletter with an overview of the latest iCNS-related developments. During most of 2024, together with Angelica, Naomi and the Executive Board, we worked hard to put together our Consortium Agreement and to finalize the paperwork before officially launching iCNS. We celebrated its start with an incredible Kick-Off meeting at theatre De Rode Hoed in Amsterdam’s city centre in early December. It was a full house, so there were plenty of chances to meet and connect with each other. We got inspired by the plans shared by our work package leaders, and talks by external guest speakers Shane Liddelow, Uwe Grether, Nikos Daslakis and Casper Hoogenraad. The interview with a depressed patient by psychiatrist Dr. Eric Ruhe was an another impressive highlight. A photo impression of this inspirational day can be found below. Since then, several PhD projects have been prepared, integrating chemistry with neuroscience. The hiring process for these PhD candidates will commence in the coming months at our partner institutes. We are delighted to announce that the first PhD students and Postdoc have already started in Leiden and Groningen. We’re excited to have you at iCNS and look forward to your future contributions! Moreover, we are saddened to share that Angelica has left iCNS as head of Team Management Support. She has done an outstanding job in helping launch the consortium, playing a crucial role in completing the Consortium Agreement on time and organizing the Kick-Off meeting. Angelica, we could not have done it without you! We had a farewell gathering at Science Park, where she received some gifts on our behalf. We thank you very much for all you did for iCNS and wish you all the very best with your new position at TNO! We are also pleased to introduce Sabina van der Zanden as the new head of iCNS Project Management. Sabina is currently part of the ICI gravitation program in Leiden and will begin her role within iCNS on July 1^st. Inge Huitinga, Paul Lucassen & Mario van der Stelt Award of Chan Zuckerberg Grant We’re thrilled that the labs of Inge Huitinga and Inge Holtman were awarded €300,000 from the Chan Zuckerberg Initiative to revolutionize neuropathological research in the Netherlands Brain Bank. This funding will enable the use of cutting-edge AI, including Large Language Models, to transform the analysis of medical records and imaging data. https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… Exciting New Additions to Our Team! Meet the brilliant minds who've recently joined us at LU and UMCG. Explore their stories below and keep an eye out for further additions via LinkedIn. New hires at UMCG (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) New hires at LU (https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…) ** A word from the first iCNS PhD student ------------------------------------------------------------ Hi everyone! I'm Lars van Abswoude and I recently started my PhD in the Molecular Physiology group under supervision of Mario van der Stelt. The main goal of my PhD is to develop celltype-specific PROTACs for various targets within the CNS. As the first PhD candidate at iCNS, I got the wonderful opportunity to attend the Kick-off meeting in Amsterdam last November. It was amazing to see how many different disciplines came together to work on the noble goal of unraveling the molecular mechanisms behind CNS related diseases. In the spirit of teamwork, we're now collaborating with Monique Mulder from Leiden University Medical Center. She's an expert on the ubiquitin-proteasome system and her in depth knowledge of this system will aid us in the biological aspects of developing a cell type specific PROTAC platform. I'm truly honored to be part of this multidisciplinary and cooperative consortium. The real strength of iCNS lies in our teamwork. By combining our expertise, we will efficiently tackle complex CNS challenges together. I'm looking forward to contributing to and witnessing iCNS's journey as it evolves. Lars van Abswoude ** Angelica’s Goodbye Party at the UvA ------------------------------------------------------------ If you have any items to share for future newsletters, don’t hesitate to send them my way! Presentations, interviews, meetings, published papers, or anything else within the iCNS framework would be welcome. Best wishes, Naomi van der Most https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… mailto:contact@i-cns.nl https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i… Want to change how you receive these emails? You can update your preferences (https://i-cns.us1.list-manage.com/profile?u=9153e18ffe39dd83583a27335&id=10…) or unsubscribe (https://i-cns.us1.list-manage.com/unsubscribe?u=9153e18ffe39dd83583a27335&i…) https://i-cns.us1.list-manage.com/track/click?u=9153e18ffe39dd83583a27335&i…

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2025

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iCNS Strategic Board