The Computational Biology and Bioinformatics group of the Brussels University (ULB) is seeking candidates for a postdoctoral position.

*Research context*:

The understanding of the biophysical mechanisms that drive single nucleobase substitutions in different regions of the human genome is one of the key questions of the post-genomic era. These mutations, whether inherited or somatic, are potentially responsible for a huge range of rare and complex diseases. The rationalization of these mechanisms is highly intricate, since base substitutions depend on the nucleotide sequence context and can be triggered by a wide range of physical, chemical or biological factors.

*Objective*: In the AtOme project, we will bridge the gap between the atomic-level characterization of mutagenesis processes and the resulting phenotypic traits. More specifically, we will investigate the role of DNA charge transport in mutational and pathogenic processes using a multiscale computational approach combining quantum chemistry, machine learning and genomics.

*Offer*: A full time postdoctoral position for 2 years. Flexible starting date, between now and October 2021. Possibility of extension through an FNRS postdoctoral research grant or a Marie Curie EC grant.

*Required:*

- PhD degree in Sciences (Bioinformatics, Bioengineer, Physics, Chemistry, Informatics).

- Excellent programming skills.

- Excellent publication record.

- Maximum 6 years research experience after PhD.

- International mobility (maximum 24 months of residence in Belgium in the last 3 years).

*Desirable:*

- Experience in the area of quantum chemistry, machine learning, and/or genome bioinformatics.

*Contact*: Please submit: (1) a cover letter detailing your background and interest in the position, (2) a full CV and (3) two references (with name, email, address, phone number), to M. Rooman (mrooman@ulb.ac.be). *Application deadline: *June 1, 2021